Squalene epoxidase as a target for the allylamines.
نویسنده
چکیده
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منابع مشابه
Inhibition of squalene epoxidase and sterol side-chain methylation by allylamines.
Irrtrotliictiori The allylamines arc a recently developed class o f synthetic antifungal agents 1 1 1 with clinical applications against pathogenic fungi. The topical antimycotic na temically active compound terbinafine inhibit a wide range of fungi. with a strictly fungicidal action in most cases [2, 31. A large number of structurally related allylamines have been synthesized; the chemistry an...
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Background: Trichophyton tonsurans is one of the dermatophyte fungi which invades the skin and hair of human. Several properties of this fungus have been investigated so far. However a few studies were carried out in the field of molecular biology of this fungus. In the present study, we tried to identify the Squalene epoxidase gene which is related to synthesis of ergosterol in this fungus. Me...
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Fig. 1. StcJrol hiosynthesis squalene to lanosterol. This enzyme has been shown to hc essential f o r fungi; Sacchurornyces cerevisiue mutants lacking this key enzyme in fact require exogenous ergosterol supplementation for growth 121. Even if these early steps in sterol biosynthesis are common to mammals and fungi, the example of the allylamines. which act on squalene epoxidase 131. shows that...
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 19 3 شماره
صفحات -
تاریخ انتشار 1991